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The compact and symmetric structure of rosmarinic acid (Table 1) binds specifically to A, inhibits polymerization into the fibrillar form, and inhibits tau aggregation [170,173], imparting protection in AD and other neurogenerative conditions

This raises concern due to the fact that MMP-2 plays a role in endometrial cancer

The secretory phase of the menstrual cycle (non-pregnant) shows an increased progesterone level and an increased number of NK cells [250]

However, it is not clear whether the effects were long lasting

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Although melatonin does not target directly bipolar symptoms, improvement in sleep is an important factor in preventing mood disturbances in patients with bipolar disorder