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In a randomized double-blind placebo-controlled trial, cortisone injections had no benefit over a saline placebo injection at either the 3-months or 6-months follow-up after the injection (Nissen et al, 2019)

Some people genetically do not have the ability to convert certain B vitamins (including B12) into their active form

"If you can work that out and make a therapy that mimics that, that is what everyone wants: an injectable or oral medication that could mimic the surgery and cause weight loss in people without the surgery," she says

doi: 10.31662/jmaj.2023-0010

it functions as a complex network of nutrients

It's also worth noting if a medication is approved by the FDA for weight loss specifically, as this often plays a big role in coverage decisions