Emerging role of mitochondrial DAMPs, aberrant mitochondrial dynamics and anomalous mitophagy in gut mucosal pathogenesis
Grade Study Research Group, Nathan DM, Lachin JM, Balasubramanyam A, Burch HB, Buse JB, Butera NM, Cohen RM, Crandall JP, Kahn SE, Krause-Steinrauf H, Larkin ME, Rasouli N, Tiktin M, Wexler DJ, Younes N, The GSRG
In both studies, the antidepressant effects were abolished by co-administration of the PPAR antagonist GW9662
PubMed Central, Brierley, Daniel I., et al
People With Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome Type 2 (MEN2) Semaglutide and other GLP-1 receptor agonists are contraindicated in people with MTC or MEN2
however, whether these changes reflect adaptive remodeling or maladaptive circadian disruption depends on the broader physiological and environmental context