For benefits leaders, consultants, and plan sponsors, the real question has shifted from Do we cover GLP1s? to: "How do we manage them in a way that protects members and the plan's bottom line?" Expanded access can absolutely improve outcomes for members who clinically need GLP1s
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ER compartments show highly organized oxygenation centers on one class of PE, and is specific toward arachidonic and adrenic FA tails 6
Factors such as previous eye problems, cardiovascular disease, and use of other medications known to increase NAION risk (like PDE5 inhibitors) should be carefully evaluated before starting GLP-1 therapy
Semaglutide stayed at 7 mg through the early part of management, giving us a steady background against which to read the antidepressant response, and the deliberate discontinuation and rechallenge that followed let us probe the doseresponse relationship head-on
