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2 Materials and methods 2.1 Study overview The Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults trial was conducted from April 2023 through May 2024 at the Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio

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In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes

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