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43,44 A couple of uncontrolled studies in healthy volunteers showed significant homocysteine-lowering effects of acute administration of NAC, 7200 mg within 24 hours, 45 and 12004000 mg once, 44 with average reductions of 44% and 22%, respectively

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Patients must avoid fasting and have a strict emergency protocol for illnesses to prevent life-threatening metabolic crises

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