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Importantly, SGLT2i have been shown to enhance heart functional capacity, as indicated by improvements in peak VO2 and performance in the 6-minute walking test (6MWT), both key metrics that reflect overall cardiovascular and metabolic health of patients

Starting low and increasing slowlya practice called titrationis the most effective way to minimize this effect

Imokawa, G

EMBO Rep 2006

Costa and Stevenson (1984) with the administration of equine chorionic gonadotropin (eCG) and pregnant mares serum gonadotropin (PMSG) showed that these components increases ovarian concentration of free LC and ALC, which shows the interaction between the direct and indirect mechanisms through cellular and hormonal regulations [82]

The first two 30-min samples were discarded to obtain stable basal values