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However, in several cases the sulfonation reaction can lead to formation of a more active metabolite compared to the parent compound as is the case for the hair follicle stimulant minoxidil (Buhl et al., 1990) or the diuretic agent triamterene (Mutschler et al., 1983)

95% CI 0.972.53, p = 0.07) or increased decline in eGFR (delta eGFR at 1 year, 3.27 ml/min/1.73 m 2