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Similarly, a high-fructose diet (HFrD) elicits metabolic and microbial changes comparable to those induced by a high-glucose diet

Plausible hypotheses for the connection between lipid peroxidation and ferroptotic cell death include that (1) compositional changes directly cause widespread membrane damage, as with the opening of pores leading to loss of ionic homeostasis, (2) local lipid domains are disrupted during lipid peroxidation, (3) compositional changes alter membrane-embedded proteins, interfering with their function, or (4) oxidized PUFA fragments are generated, releasing reactive species that disrupt other essential cellular processes or activate downstream lethal events

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Both amino acids are involved in complex metabolic pathways

Systems pharmacology of adverse event mitigation by drug combinations