tirzepatide side effects long term Effects: Complete Guide For 2026 Understanding Tirzepatide – Juno Clinic

Lv Y, Lei N, Wang D, An Z, Li G, Han F, Liu H, Liu L

Biochimica et Biophysica Acta, 1792 (10), 931940

For semaglutide, common side effects include nausea, diarrhea, and possible loss of appetite

As mentioned, this can affect the lip, hard palate, and soft palate based on multiple factors

Others may experience more discomfort in the thigh

After 52 weeks of treatment, the proportion of participants in the oral semaglutide group achieving an A1C of less than 7.0% was 58.3% (treatment-policy estimand) and 62.8% (trial-product estimand), compared with 25.2% (treatment-policy estimand) and 28.3% (trial-product estimand) for the group receiving 100 mg of sitagliptin daily