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This action deactivates the NF-B/GSDMD signaling pathway, with phosphorylated NF-B p65 expression reduced by 30%, and downregulates mRNA and protein levels of pyroptosis-related molecules (Caspase-1, GSDMD, NLRP3) by 50%70%

[DOI] [PubMed] [Google Scholar] 42.Venketaraman V., Rodgers T., Linares R., Reilly N., Swaminathan S., Hom D., Millman A.C., Wallis R., Connell N.D

Xiao B, Zhang M, Viennois E, Zhang Y, Wei N, Baker MT et al (2015) Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles

doi: 10.1016/j.mehy.2020.110394 130 FerrarottiIOttavianiSBalderacchiAMBarzonVDe SilvestriAPiloniD

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10.1158/1078-0432.CCR-16-2272 12 BeddowesE.SpicerJ.ChanP