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It's worth noting that with continued use, some patients develop tolerance to this gastric-slowing effect (tachyphylaxis)
McGown recommends the following: Start at the lowest dose and then increase slowly based on the manufacturers recommendations
5 mg/mL concentration: 50 units = 2.5 mg (starting dose, weeks 1-4) 10 mg/mL concentration: 50 units = 5 mg (moderate dose, weeks 5-8) 15 mg/mL concentration: 50 units = 7.5 mg (mid-range dose, weeks 9-12) 17 mg/mL concentration: 50 units = 8.5 mg (between standard tiers) 20 mg/mL concentration: 50 units = 10 mg (high dose, weeks 13-16) 30 mg/mL concentration: 50 units = 15 mg (maximum dose, week 21+) Notice the pattern
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