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The semaglutide side effects users reported most often in clinical trials were: Nausea Diarrhea Vomiting Constipation Abdominal pain Headache Fatigue More than 20% of trial participants reported these side effects, with 44% reporting nausea and 30% reporting diarrhea compared to 24% or fewer for vomiting, constipation, and abdominal pain

Mild to moderate nausea or occasional upset stomach as your digestive system adapts to the regular Semaglutide molecule

When food remains in your stomach for a longer period, there is more opportunity for stomach acid to splash back up into your esophagus, the tube connecting your throat and stomach

Clinical trials have consistently shown that this approach results in a higher average reduction in body weight compared to GLP-1 agonists alone

Safety, Risks, and Provider Oversight Lower dose is not the same as lower risk

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