This axis regulates the bodys complex energy metabolism network through the exchange of hormones, cytokines, and nutritional metabolites
A phase 2 trial of gemcitabine plus toripalimab for cisplatin-ineligible patients with recurrent or metastatic nasopharyngeal carcinoma
doi:10.1002/hep.510270121 Willems P, Wanschers BF, Esseling J, Szklarczyk R, Kudla U, Duarte I, Forkink M, Nooteboom M, Swarts H, Gloerich J, Nijtmans L, Koopman W, Huynen MA (2013) BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion
This reaction depends on the catalytic selenocysteine residue of GPX4, which is directly targeted and inactivated by ferroptosis inducers such as RSL3
Based on this knowledge, one would envisage the development of antidotes such as NAC, which would be effective even for some time after the metabolic phase of toxicity was complete
Oxidative stress disrupts melatonin production, raises nighttime cortisol, and interferes with deep sleep cycles
