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But the problem runs deeper than simple tolerance

Additionally, foods such as soy products, vegetables, fruits, and cereals, along with their bioactive components, have been found to play a significant anti-inflammatory role in the progression of IBD (180192) ( Table 1 )

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Likewise, restraint stress rapidly modulated KP enzyme expression in rats, with amygdala IDO increasing within 1 h, amygdala KMO and kynureninase rising by 4 h, hippocampal TDO decreasing within 4 h, hypothalamic TDO upregulated at 4 h, and medial prefrontal cortex kynureninase reduced shortly after stress with effects lasting at least 24 h [70]

Issues such as pinched nerves in the back or foot neuropathy can cause abnormal signals to the muscles, leading to cramps