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Apoptosis can be initiated via three principal pathways: the extrinsic (death receptor) pathway, the intrinsic (mitochondrial) pathway, and the endoplasmic reticulum (ER) stress pathway (Figure 2A)
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Carson et al
A: Exenatide once weekly provides a sustained, constant, day-long pharmacologic elevation in the plasma exenatide concentration
This means that during postnatal development in diseased retinas, greater excretion of GSSG, into extracellular space where it get hydrolyzed, could lead to an increase in the [GSH]/[GSSG] ratio
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