Hims & Hers said its oral semaglutide "empowers providers to tailor treatment plans specifically for those who prefer to avoid needles or need smaller doses to help to balance side-effects." It added that its compounding operations "adhere to all federal and state standards for compounding, and all active pharmaceutical ingredientsin compounded treatments are sourced exclusively from FDA-registered facilities." In its statement, Novo Nordisk said the American Diabetes Association's Obesity Association recently published new standards of care, which "discourage the use of compounded GLP-1s due to safety, quality, and effectiveness concerns." Meanwhile, FDA Commissioner Marty Makary delivered some encouraging news to Novo Nordisk, after pledging "swift action against companies mass-marketing illegal copycat drugs, claiming they are similar to FDA-approved products."
Semaglutide lowered fasting glucose after the first dose
The challenge is that almost all the research is in rodents
A rare but serious adverse effect is lactic acidosis, which occurs predominantly in patients with renal impairment, severe dehydration, or acute illness
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Retina 2018;38(12):22932300
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