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They also modulate insulin secretion in a glucose-dependent manner, improving glycemic control without significantly increasing hypoglycemia risk in non-diabetic patients

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Roemer, S

Clinical trial participants who achieved the most significant outcomes consistently combined pharmacological treatment with dietary modification and increased physical activity

Accordingly, the American Diabetes Association recommends the use of GLP-1RAs with or without metformin in patients with atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), and/or heart failure (HF) [25]