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Fast forward four years, and the FDA had expanded approval for chronic weight management under a different brand name

Indeed, glutamate is reported to constrict pial arterioles whereas inhibition of glutamate by an ionotropic receptor antagonist dilates arterioles 18

Participants routinely lost considerable amounts of weight, and the effects lasted for extended periods of time

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Why the FDA is concerned about unapproved GLP-1 pills (including tirzepatide) The FDA has issued detailed warnings about unapproved GLP-1 drugs marketed for weight loss, including products claiming to contain tirzepatide (official FDA safety alert)