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Of note, however, in a 40 week Phase 3 study of overweight/obese individuals with type 2 diabetes, 36 mg of orforglipron taken orally once daily achieved reductions in HbA 1c of ~12 mmol/mol (1.07%) and in body weight of 5.9 kg (placebo subtracted) with an adverse event profile similar to that of the established GLP-1RA class [83]
A 40-week study found that tirzepatide, the active ingredient in Mounjaro, reduced blood sugar levels (through measurement of glycated hemoglobin, also known as A1C) by up to 2.30%
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As research continues to evolve, clinicians benefit from staying informed about emerging therapies, safety considerations, and evolving treatment strategies
This is why cannabis history belongs in the first conversation, not only after problems appear