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This selfish protective inhibition may form the potential pathological foundation for the neurocognitive symptoms and delayed fatigue characteristic of PEM (147, 181).The interaction between energy depletion and neuroinflammation intensifies a potential cycle of energy depletion - inflammation amplification, clinically manifesting as delayed and persistent mental fatigue, cognitive dysfunction, and emotional disturbances
Although oxidative stress was defined originally as a balance between oxidants and antioxidants systems, an equilibrium among antioxidant strategies is needed to avoid the generation of oxidants and ROS (Mari et al., 2010)
Pgd2/Ptgdr2 signaling restricts the self-renewal and tumorigenesis of gastric cancer
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