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The stop-start pattern of running out early, going without for several days, and then resuming creates more dramatic concentration swings than consistent weekly dosing, potentially worsening the very wearing-off effect that prompted the frequency increase in the first place

P = .002)

But they also faced a new kind of competition

The cost per milligram decreases significantly with larger vial sizes a 10mg DSIP vial typically costs 4060% less per milligram than a 2mg vial

It also slows down the digestive process, which lowers appetite in most patients