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Similarly, with the N-methylated analogues ( 1.65 , 1.70 , and 1.71 ), all of Compounds 1.65 , 1.70 , and 1.71 showed significantly higher cell viability than the untreated groups
While treatment with RSL3 alone did not decrease tumour size, treatment with cisplatin reduced mean tumour size (Fig
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In corneal epithelial cells stimulated by hyperosmosis or cigarette smoke extract (CSE), both ferroptosis and apoptosis occur simultaneously (133)
Conversely, ACSL4 expression, along with levels of ROS, MDA, 4-HNE, Fe 2+ , and -synuclein, were markedly elevated, thereby exacerbating ferroptosis and lipid peroxidation in the brain
In addition, adaptive and personalized KD strategies are particularly important in translating metabolic therapies from controlled clinical environments to real-world settings with variable healthcare infrastructure
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