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doi: 10.1001/jamanetworkopen.2026.2450

This means semaglutide clears more slowly and has a longer effective duration per dose

This does not change the 72-hour minimum rule, but it means that the side effect profile at a given dose may shift as your weight changes

A comparison of the two states of GDH can also be seen in the animation below

Dosing and Administration: What the Protocol Actually Looks Like Both medications are administered via weekly subcutaneous injection a small, pre-filled auto-injector pen that most patients find far less intimidating than anticipated