6 Obesity drugs are expanding beyond BMI reduction The therapeutic scope is moving toward comorbidity modification: type 2 diabetes prevention, glycaemic control, cardiovascular risk reduction, heart failure with preserved ejection fraction, obstructive sleep apnoea, chronic kidney disease and MASH/metabolic liver disease
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The fact that GSH production is required during conditions that cause overproduction of ERgenerated ROS suggests a role for GSH in their elimination
10.1016/j.redox.2016.05.003 15 ChenJ.TalwalkarJ
These models were first used to examine strategies to decrease BBB-dependent pharmacoresistance in neuropathologies
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