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Each has documented research effects in mammalian models with relevance to aging physiology
The depletion of cytosolic glutathione by import into the nucleus induces glutathione synthesis, which accelerates the accumulation of GSH and allows the maintenance of a reducing redox environment under stress conditions (Diaz Vivancos et al
The following subsections outline key smart material strategies and functional outcomes, highlighting how hybrid nanomaterials through pH-responsive systems, peptide or polysaccharide conjugation, multifunctional hydrogels, antibiotic resistance modulation, and enzyme-based nanozymes translate these dual actions into clinically relevant wound-healing solutions
However, a major therapeutic limitation stems from the fact that quercetin has poor solubility and absorption capacity, as well as low brain bioavailability 192 , and does not cross the normal BBB with high efficiency (Table 3) 193
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