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Kaempferol reverses the abnormal elevation of TCA cycle-related metabolites such as succinic acid and citric acid in the plasma of PAH rats by regulating amino acid metabolism and arachidonic acid metabolism, downregulates the pro-inflammatory metabolite 12-HETE, upregulates the anti-inflammatory metabolite DHA, and inhibits the expression of PTGS1 (Yi et al., 2022)

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