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These agonists can facilitate the transformation of visceral white adipose tissue (WAT) into brown adipose tissue (BAT), thereby stimulating BAT thermogenesis through sympathetic nervous system activation to enhance energy expenditure (110112)

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One of the possible reasons for this is that metformin inhibits sodium-glucose cotransporter1 (SGLT1) on small intestinal epithelial cells, decreasing the intra- and extracellular Na + concentration gradient, thereby inhibiting intestinal glucose absorption and increasing glucose utilization (Lenzen et al., 1996

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Injectable forms, such as weekly semaglutide or dulaglutide, provide sustained drug levels

Torreya grandis oil augmented the abundances of Firmicutes and Actinobacteria along with Firmicutes/Bacteroidetes ratio, and declined those of Bacteroidetes, Proteobacteria, and Verrucomicrobiota at the phylum level, while exhibited anti-obese (88) and anti-Alzheimers disease (89) effects