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As pointed out by De Berardinis et al., the changes in tumor ammonia metabolism between in vivo and in vitro experiments may differ significantly (255)

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Zarnowski R, Noll A, Chevrette MG, Sanchez H, Jones R, Anhalt H, Fossen J, Jaromin A, Currie C, Nett JE, Mitchell A, Andes DR (2021a) Coordination of fungal biofilm development by extracellular vesicle cargo