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There is concern for the high incidence of weight gain with discontinuation." Internal Medicine "1

A Comprehensive Comparison in the Realm of GLP-1 Receptor Agonists In the evolving landscape of diabetes management, GLP-1 receptor agonists have emerged as potent players, offering not only blood sugar control but also notable benefits in weight management

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Clinical Significance Despite the availability of effective statins and injectable PCSK9 inhibitors, many high cardiovascular risk patients continue to fail to achieve recommended LDL cholesterol targets

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Mechanistically, LONP1 downregulation triggers mitochondrial accumulation of its substrate, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), thereby disrupting mitochondrial function and accelerating CKD progression