Educate patients or caregivers on the signs and symptoms of hypoglycemia [see Warnings and Precautions (5.4)]
As a dual-action GLP-1/GIP receptor agonist, Zepbound (tirzepatide) is among the most effective prescription medications for chronic weight management currently available
In a substudy of SURPASS-3 involving patients with type 2 diabetes and a liver index more than 60, tirzepatide was found to lower liver fat content considerably compared to insulin [36]
Mosegaard S, Bruun GH, Flybjerg KF, Bliksrud YT, Gregersen N, et al
Ketone testing is not routinely needed unless you are unwell, have very high glucose levels, or experience symptoms such as excessive thirst or unusual fatigue
Pre-autonomic neurons are located in the PVN 24 and are partly controlled by inhibitory GABA projections from the lateral hypothalamus (LH) acting on PVN GABA A receptors (GABA A R) 25,26,27