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Chronic persistent hypoxia is recurrent in chronic lung diseases where O 2 levels remain constantly low, while chronic IH is characteristic of obstructive sleep apnea, characterized by an intermittent pattern of episodes of hypoxia and reoxygenation [133]
B.et al (2012b)
Rodas-Moya S, Giudici FM, Owolabi A, et al
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Sensitivity to platinum-based chemotherapy drugs was then compared in A2780 and A2780/GSTP1 cells and significant differences in chemosensitivity observed following treatment with cisplatin (2.28-fold decrease in IC 50, P =0.03, Figure 2B) and carboplatin (4.83-fold decrease in IC 50, P =0.007, Figure 2C), and a less pronounced decrease in sensitivity to paclitaxel (1.58-fold increase in IC 50, P =0.02, Figure 2D)