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cited to illustrate range of doses explored in mood disorders and that even lower doses had some effect

These perceptions about the changes in receptors, thyroid hormone metabolism, and synthesis have been augmented by research involving transgenic mouse models that have thyroid hormone receptors and TSH receptor mutations

- [Retatrutide Phase 2 Trial Supplementary Appendix: Drug Preparation]( *New England Journal of Medicine*, 2023

Research also suggests it may have direct effects on the heart, that help keep the heart and blood vessels healthy

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They help with hydration, normal energy metabolism, and recovery, so its easier to stay consistent with the habits that do move the scale (nutrition, training, sleep)