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Inflammation-associated oral mucosal melanin hyperpigmentation Under circumstances that are not well defined, certain inflammatory cytokines and mediators have the capacity to promote the production of -MSH by oral melanocytes and keratinocytes and to upregulate the expression of MC1R of melanocytes resulting in increased biosynthesis of melanin

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Potential Links to Hair Follicle Biology Research has also examined the peptide in relation to dermal papilla cells (DPCs), specialized fibroblasts implicated in hair follicle development

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