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Phentermine is a stimulant that works similarly to an amphetamine to reduce appetite, while topiramate is an anticonvulsant that can also decrease appetite

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It does not yet say: clinically proven for human longevity

In DIO mice, PL7737 achieved significant weight reductions after just one day of treatment when orally administered once-daily at 10 and 30 mg/kg (137)

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PMID 12140136