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Riordan first became aware of this therapy in the early 1980s, when a 70-year old patient suffering from metastatic renal cell carcinoma that had spread to his liver and lungs came to the clinic requesting IV ascorbate infusions

In ABA- and ROS-mediated stress responses, ASC exhibits this biphasic response to environmental stress ( de novo synthesis and regeneration of ASC to scavenge the accumulated ROS and thus eliminate oxidative damage, to enhance plant abiotic stress tolerance (Zhang et al., 2020)

Step 2: Start low and go slow

Cancer-pathway concern IGF-1 signaling is mitogenic and anti-apoptotic, two properties relevant to cancer biology