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The outer thigh and back of the upper arm are also appropriate

Gut barrier damage and endotoxemia: mechanisms and effects Under hyperthermic conditions, superficial blood vessels dilate to dissipate heat, leading to reduced blood flow to visceral organs (especially the intestinal mucosa) in a murine heat stress model, which in turn causes damage and apoptosis of intestinal epithelial cells, increased intestinal epithelial permeability, and impaired intestinal mucosal barrier [17]

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Mechanistically, MOTS-c triggers activation of the cellular energy sensor AMPK (5 AMP-activated protein kinase), which in turn enhances glucose uptake and utilization in cells

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