GHK-Cu is also a regular constituent in human plasma, existing at approximately 200 ng/ml at age 20 and dropping to 80 ng/ml at age 60
A predicted site in selenoprotein P (SELENOP, Figure 2C) is at position 56, 3 residues prior to the first selenocysteine, such that cleavage here would likely interfere with the N-terminal redox activity, possibly without affecting the Se-transport function of the rest of the protein
Additionally, one study of over 400 human subjects found different regression profiles for selenium and GPx-1 activity for each genotype: the correlation of GPx-1 activity with plasma selenium concentrations was higher for the Pro/Pro genotype than the Leu/Leu genotype, providing evidence that GPx-1 genotypes can modulate the expression of GPx-1 in response to selenium in vivo (183)
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