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3d), sustained plasma Exe4 concentrations and therapeutic effects were observed in DIO mice, owing to the compensatory high gene expression at the Alb gene in hepatocytes

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For Lebers optic atrophy or smokers blindness, the usual dose starts at 1000mcg, given daily for 2 weeks, followed by twice weekly

Lohith TG, Osterweil EK, Fujita M, Jenko KJ, Bear MF, Innis RB

Because the TCA cycle and the electron-transporter channel require NAD + and NADH, respectively, an optimal NAD/NADH ratio is needed for efficient mitochondrial metabolism