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Pioglitazone use and heart failure in patients with type 2 diabetes and preexisting cardiovascular disease: data from the PROactive study (PROactive 08)

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(Closely related class: dual GIP/GLP1 twincretin, often discussed alongside GLP1s due to overlapping benefits) Brands: Mounjaro (diabetes), Zepbound (weight management) Administration: Onceweekly subcutaneous injection via prefilled pen

Acute kidney injury has been reported, typically in the context of severe dehydration from gastrointestinal side effects

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During active weight loss, appetite may decrease, motivation may be high, and progress may be visible