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There is a virtual catalog of speculated root causes of neurodegenerative diseases ( Neuronal activity is energetically demanding, requiring substantial amounts of adenosine triphosphate (ATP), as reflected in the disproportionate oxygen and glucose consumption of the brain compared with the rest of the body ( Various dynamic models of brain metabolism have been developed over the decades

Most chemotherapy drugs show a steep dose-response curve, meaning even a small reduction in dose may lead to a significant reduction in tumor cell killing (Honkoop 1995

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