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The mevalonate (MVA) pathway can affect the synthesis of GPX4 by regulating the maturation of selenocysteine tRNA, thereby regulating the occurrence of ferroptosis

doi: 10.1016/j.cgh.2021.04.028 98 ZschbitzSChengT-YDNeuhouserMLZhengYRayRMMillerJWet al

Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis

Additionally, direct supplementation of monounsaturated fatty acids (MUFAs) in the diet to replace PUFA, which is prone to lipid peroxidation on cell membranes, can prevent the accumulation of lipid ROS and the occurrence of ferroptosis [295]

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