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Adding more water (5 mL) increases the daily draw to 10 units (easier to measure) but does not solve the shelf-life problem

The US Department of Health and Human Services announced the names of the first 10 drugs earlier this year

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Simtuzumab (SIM) SIM is a monoclonal antibody against the enzyme lysyl oxidase-like 2 (LOXL-2) responsible for the cross-linking of collagen and overexpressed during the fibrosis progression [80]

These pleiotropic effects reinforce their clinical positioning but also highlight the complexity of their pharmacodynamic profile