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The references below summarise the mechanism-of-action and translational rat-model evidence base most relevant to the orthopedic and connective-tissue repair claims discussed in this article

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Impairment of judgment and coordination begins at low levels but escalates to dangerous conditions at higher levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 1001

Severe deficiency : Weekly or biweekly injections may initially be required to correct anemia and neurological symptoms

The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For