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From the 8th day, the mice in NM group were treated with Folium sennae decoction 10 g/(kgday) by gavage every afternoon, 0.4 mL/time, once a day for 7 consecutive days

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Some patients have also experienced a hypersensitivity reaction following intramuscular injection that has resulted in anaphylactic shock and death

Additionally, the crossover design improves statistical efficiency, as the variance between participants is reduced, allowing for a smaller sample size while maintaining the ability to detect significant effects