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DOI: 10.3390/ijms24021724 68

Gut elimination of uric acid, which couples transport into the small intestinal lumen and colonic bacterial urate oxidation by uricase, normally removes ~200 mg of uric acid daily in humans ( Figure 1 - 3A ), but this elimination pathway has limited potential for adaptive increases in capacity beyond ~100 mg more daily

139,140,141 Although dual agonists show advantages in efficacy, their safety and tolerability continue to be a focus of ongoing monitoring