As oxidative stress can be involved in the etiology of hypertension and cerebrovascular disease, polymorphic genes encoding for GPxs can be putative candidates for the genetic susceptibility to CS
Furthermore, in vivo experiments showed that CNS exhibited therapeutic effects comparable to those of fluoxetine, effectively ameliorating symptoms of anxiety, despair, and anhedonia while also inhibiting microglial activation in the hippocampus of mice subjected to CUMS
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