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they may potentially do so via the relatively permeable CVO or through endocytosis and transcytosis of vascular endothelial cells to reach the deep brain (143145)

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Brain Res 724(1):121124 Shapiro RE, Miselis RR (1985) The central neural connections of the area postrema of the rat

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Interestingly, the same research group recently identified an anti-inflammatory role for p62, a modulator of the KEAP1NRF2 axis, in the same DKO* model [9], suggesting a broader oxidative-stress circuitry governing psoriatic inflammation