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Involvement of nuclear factor-kappa B (NF-B) in methotrexate-induced intestinal injury NF-kB is a key regulator of inflammation that is involved in the synthesis of inflammatory mediators and activation of pro-inflammatory cytokines (Liu et al

Room temperature storage accelerates degradation significantly

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Calcium ions and oxidative cell injury

Hyperglycemic conditions not only reduce NO production but also enhance NF-B activation and promote inflammatory gene expression and leukocyte recruitment [165]