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[DOI] [PubMed] [Google Scholar] 88.Rao M.V., Purohit A.R

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Obesity among adults has more than doubled since 1990 with one in eight people in the world now living with obesity, The Lancet says, while the World Obesity Federation warns that more than half the world's population -- or more than four billion people - will be classed as obese or overweight by 2035 if action is not taken

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[Additionally, you need to] make the molecule permanently or reversibly bigger [to avoid renal excretion]

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doi:10.1002/chem.202003788

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GLP-1 reduces glucagon secretion from the pancreas

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